![]() Laganà A, Veneziano D, Russo F, Pulvirenti A, Giugno R, Croce CM, Ferro A (2015) Computational design of artificial RNA molecules for gene regulation. Methods Mol Biol 1756:269–279ĭas PK, Asha SY, Abe I, Islam F, Lam AK (2020) Roles of non-coding RNAs on anaplastic thyroid carcinomas. ![]() Islam F, Gopalan V, Lam AK (2018) RNA interference-mediated gene silencing in esophageal adenocarcinoma. Here we illustrate a simple protocol for the formulation of siRNA-loaded lipid particles by hydration of freeze-dried matrix (HFDM) method for effective delivery of target specific siRNA to papillary thyroid carcinoma cells. Thus, a simple method to prepare stable PEGylated siRNA-loaded lipid particles could provide better systemic delivery system in treating various cancers, including papillary thyroid carcinoma. Also, PEGylation permits the accumulation of the liposomes-loaded siRNA at the tumor sites with defective vasculatures such as enhanced permeability and retention phenomena. Polyethylene glycol (PEG) has been used in siRNA-liposomes formulation to minimize reticuloendothelial uptake. Nonetheless, systemic delivery of siRNA via cationic lipid particles is often poor due to rapid uptake by reticuloendothelial organs, resulting in decreased delivery of these particles to the site of interest. The most effective methods involving cationic liposomes delivery to cells. However, the systemic delivery of interested siRNA via non-viral methods remains a major challenge with large numbers of polymeric and liposomal systems being tested. siRNA mediated gene has been widely investigated for its utility in treating various diseases including cancer. Pharmacologically it can be achieved by introducing of small (19–21 base pairs) dsRNA molecules known as small interfering RNA (siRNA) targeting interested genes. files') that have beenįind $HOME \( ! -regex '.*/\.The discovery of RNA interference (RNAi) has opened a new strategy in cancer therapy, especially by silencing target genes. To show all files in HOME directory (except the hidden '.To get rid of the star next to the email address in Thunderbird 3.-, add.Go to Edit -> Preferences -> General -> Config Editor and change the following property To auto-hide tab toolbar in Thunderbird 3.*-, thus not wasting some screen space,.SmartTemplate4 + Stationery (flexible email templates). Mail Merge (customised newsletter sender see more details), Manually Sort Folders (to change the order of accounts in the left panel), Show All Body Parts (switch between HTML and attachment mode),Ĭopy Folder mod (backup/restore IMAP to/from local folders), Signature Switch (to add a signature on/off button), Outgoing Message Format (to set "plain text and HTML" instead of auto-detect), Message Archive Options (included in version > 3.1 but still useful), Some indispensable add-ons for Thunderbird 60.9:.Use firefox -no-remote to run a new firefox instance rather than opening another window to existing process.If something is wrong with Firefox, you can create and launch a temporary blank new profile by typing (from the command line)įirefox -ProfileManager (or firefox -P) and then hitting the button.> popup_menu.html -> replace "To Read" with "All bookmarks" mozilla -> extensions -> pinboard-webextension.xpi -> main.js -> open_window() -> width: 900 Pinboard-quantum and pinboard-webextension. All-In-One Sidebar, Copy All Urls, CuteMenus2, Mr Tech Toolkit (misc utilities) PinboardButton,, Google Notebook (web-services) 41+) introduced 'add-on verification' feature, setĪbout:config -> = FalseĪdblock Tab Mix Plus and FaviconizeTab (tab-management) (where 3.6 is the first two numbers of Firefox's version).Ī better way, however, is to install a Compatibility Reporter that does this automatically for you. To turn off the compatibility check of add-ons, you can create a new property setĪbout:config -> New -> Boolean -> extensions.checkCompatibility.3.6 = False.To switch off the irritating "smart" search in the address bar of Firefox 3, useĪbout:config -> = False.To open pdf-documents with a stand-alone application instead of loading to the Firefox tabĪbout:config -> New -> String -> plugin.disable_full_page_plugin_for_types = application/pdf.To re-enable a stand-alone Preferences Dialogue in Firefox 38+, type in about:config in the address field and setī = false = false.Visual Studio, Borland C++ Builder, Intel C, QT, Java ImageJ (morphology analysis and image processing) JabRef (LaTeX oriented BibTeX database), Zotero PuTTY + RealVNC/TightVNC WinSCP, Far+NetBox Essential Scientific Software: Trans-platform EquivalentsįireFox (except IE-specific services like Outlook Web Mail)
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